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Laron Syndrome Laron syndrome is a rare human genetic disease that causes dwarfism. People with Laron syndrome lack certain receptors important for body growth. They have normal levels of growth hormone produced by the pituitary gland, but without the cell receptors, the hormone is unable to bind to cells and promote growth. Laron syndrome was first identified in 1966. People with this disorder, also known as Laron dwarfism, usually develop symptoms at or shortly after birth. Studies suggest the incidence of Laron syndrome is higher in girls than in boys. In addition to a short stature, people with the syndrome sometimes have deep set eyes, smaller hands and feet and a high-pitched voice, and may be prone to obesity. LS is an inherited disorder consisting of a genetic defect transmitted in an autosomal recessive fashion. Consanguinity has been a major contributor to its development in described populations. Treatment of Laron syndrome with human growth hormone is ineffective because people with the disease lack the receptors they need to use the growth hormone.
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