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| Plants Mimic Estrogen in Animals |
Researchers say certain plants long used to treat gynecological problems act like estrogen in animals and may be dangerous to women who consume these plants without really needing the estrogen. Scientists at the University of Pittsburgh Medical Center in Pittsburgh, Pa., found that the plants vitex, dang gui, American ginseng and cohosh produce estrogen-like effects in studies involving rats. The researchers tested the effects of these plants in rats whose ovaries had been removed so they could not produce estrogen. After 30 days of receiving these plant compounds, researchers found the uterus in every rat had grown heavier, indicating the uterus was responding the same way it would to estrogen. Researchers also found the rats had low levels of luteinizing hormone (LH), which is produced by the pituitary gland to create estrogen. When there are high levels of estrogen in the body, LH production is turned off. "These findings confirm reports that these plants relieve menopausal symptoms, especially hot flashes," says researcher Patricia Eagon. "However, we still need to conduct further pre-clinical tests with these substances to study their long-term effects and to ensure they are safe to use. Our results should signal a strong note of caution to women who want to relieve menopausal symptoms, but who have a family or personal history of breast or uterine cancer." Vitex is a Mediterranean plant used to treat menopause. Cohosh is an American Indian treatment for menstrual pain and menopausal symptoms. Dang gui and ginseng are Chinese herbs used for different gynecological ailments. This study was reported at the American Association for Cancer Research in Philadelphia. |