Adverse effects of Amphetamines

Amphetamine, Dextroamphetamine, Methamphetamine.

Amphetamines are central nervous system stimulant.  Amphetamines  (dexedrine) are being miss used by many.  Psychological dependence and tolerance may occur with amphetamines following prolonged use or high doses.

Amphetamines are used in the treatment of Attention-deficit hyperactivity disorder. 

Amphetamines are indicated as an integral part of a total treatment program that includes other remedial measures (psychological, educational, social) for a stabilizing effect in children  with attention-deficit hyperactivity disorder, characterized by moderate to severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.

Due to their high potential for abuse, amphetamines are not recommended for use as appetite suppressants. Amphetamines should not be used to combat fatigue or to replace rest in normal subjects.

More frequent adverse effects  
CNS stimulation - false sense of well-being; irritability; nervousness; restlessness; trouble in sleeping, drowsiness, fatigue, trembling, or mental depression may follow the stimulant effects.

With prolonged use or high doses
Cardiomyopathy - chest discomfort or pain; difficulty in breathing; dizziness or feeling faint; irregular or pounding heartbeat; unusual tiredness or weakness. Irregular heart beat.

Increase in blood pressure

Psychotic reactions - mood or mental changes

Less frequent adverse effects

Allergic reaction - skin rash or hives 

Chest pain, fast or pounding heartbeat; increased sweating

Tourette's syndrome - uncontrolled movements of the head, neck, arms, and legs

Hyperthermia - extremely high body temperature

Blurred vision

Changes in sexual desire or decreased sexual ability

Constipation, diarrhea loss of appetite nausea stomach cramps or pain, weight loss, vomiting, dizziness lightheadedness headache; dryness of mouth or unpleasant taste. 

Symptoms indicating possible withdrawal - after medication is discontinued

Mental depression; nausea stomach cramps or pain vomiting; trembling; unusual tiredness or weakness.

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